Pioglitazone vs glimepiride to evaluate the effect of on renal function tests in type 2 diabetes in patients

ABSTRACT

To compare the improvement in renal function tests [RFTs] of type 2 diabetic patients who were taking glimeperide alone and this drug in combination with piogliatzone and pioglitazone alone. Data was analyzed using ANOVA. P < 0.05 was taken as significant. Randomized prospective study. This study was conducted in the diabetic clinic of Fauji Foundation hospital Rawalpindi and the tests were analyzed in the Biochemistry Lab of Islamic International Medical College Rawalpindi. 12 weeks. Blood glucose levels were determined by glucose oxidase method [globe marketing GD Italy], HbA1c by Microlab 200, urea/creatinine /uric acid by Selectra E and micro albumin by Spin colour. No significant differences were observed for the variables of hemoglobin A1c, uric acid and urinary albumin P >0.05. Significant decreases were observed in the levels of fasting plasma glucose, urea and creatinine P< 0.05. In patients with type 2 diabetes pioglitazone and the combinations of glimepiride with pioglitazone produced significant improvements in measures of glycemic control and RFTs