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Effect of metformin on diabetes mellitus prevention in pregnant women with risk factors
Journal of Family and Reproductive Health. 2010; 4 (4): 165-168
em Inglês | IMEMR | ID: emr-113414
ABSTRACT
This study evaluated the efficacy and safety of metformin on prevention of gestational diabetes mellitus in women with high risk of GDM. Total number of 189 pregnant women aged between 25 to 35, and 10 to 14 weeks pregnancy, admitted to Mirza Koochakkhan Hospital, Tehran in January 2008 - January 2009 entered to this randomized controlled clinical trial. The women had one of the three risk factors; history of GDM, family history of diabetes, or BMI >/- 30 kg/m[2], with normal results in the glucose challenge test [GCT] or the glucose tolerance test [GTT]. Subjects were randomly split to two groups; 63 women [group A] who received metformin [500 mg, twice a day] and 126 women [group B] did not use metformin. Incidence of gestational diabetes was compared between two groups. The incidence of gestational diabetes was significantly different between two groups [%1.4 in group A,%15.4 in group B] [p<0.001]. The study also showed that the insulin requirement was significantly different between two groups after developing GDM [group A%3.6, group B%9.5, p=0.001]. Using Metformin can effectively reduce the incidence of GDM in pregnant women at risk
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Índice: IMEMR (Mediterrâneo Oriental) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: J. Fam. Reprod. Health Ano de publicação: 2010

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Buscar no Google
Índice: IMEMR (Mediterrâneo Oriental) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: J. Fam. Reprod. Health Ano de publicação: 2010