Development of new therapeutic strategies in gynecological cancers in Iran by utilizing xenograft model of ovarian adenocarcinoma

ABSTRACT

To evaluate the potentiality of OVCAR-3 cell line of ovarian adenocarcinoma as a xenograft model for ovarian adenocarcinoma in nude mice. The cell line isolated from advanced human ovarian adenocarcinoma, were inoculated to eight nude mice and two months later. Established tumors were transferred to pathology laboratory to be prepared by H and E staining and immunohistochemical staining with CA125 antibody. Study of H and E slides showed advanced adenocarcinoma. The CA125 Tumor marker was also positive in tumoral tissue. Established tumors showed excellently the characteristics of ovarian adenocarcinoma. This model can be used to evaluate new treatment strategies