Immunoglobulin E in renal failure

In this work serum IgE level was found significantly higher in patients with chronic renal failure [32 patients] in comparison to normal control subjects [10 subjects].The highest level was in patients under conservative treatment followed by patients under haemodialysis then patients under dialysis.We did not find any correlation between age, sex, blood urea or serum creatinine on one hand and serum IgE level on the other hand. IgE level was found positively related to the duration of peritoneal dialysis.The explaination for this may be due to possible alteration in T-cell regulation of immunoglobulin synthesis. Active molecules have been described to regulate the function of T-cells controlling IgE production. If these molecules are proved later to be in the range of middle molecules, it would explain our findings. This needs more investigations and work to reach to the truth