Interpretation of maturing trilineage hematopoiesis

ABSTRACT

Normal adult bone marrow occupies the medullary spaces of large bones. The main function of bone marrow is the production of blood cells [hematopoiesis]. Bone marrow is composed of a matrix requisite for hematopoiesis as well as erythriod precursors, myeloid precursors with monocyte macropliage system, megakaryocytes, lymphocytes, plasma cells, blood vessels and stroma. Interpretation of bone marrow maturing trilineage hematopoiesis includes the assessment of the maturation seq uence and morphologic features for each lineage. This review presents detailed guidelines for interpretation of bone marrow maturing trilineage hematopoiesis according to the cell line and the pathologic condition