Your browser doesn't support javascript.
loading
Effects of ovariectomy and ascorbic acid supplement on oxidative stress parameters and bone mineral density in rats
LJM-Libyan Journal of Medicine. 2011; 6: 1-9
em Inglês | IMEMR | ID: emr-114152
ABSTRACT
The aim of this study is to investigate the effects of ovariectomy on bone mineral density [BMD] and oxidative state in rats, and the alterations in these effects that vitamin C supplementation may produce. Twenty female Wistar albino rats were randomly divided into three groups control [C, n=6]; ovariectomy [O, n=7]; and ovariectomy+vitamin C supplement [OV, n=7]. Oxidative stress [OS] was assessed 100 days postovariectomy by measuring the activity of several enzymes, including catalase [CAT], superoxide dismutase [SOD], and glutathione peroxidase, as well as the concentrations of malondialdehyde [MDA], nitric oxide [NO], and total sulfhydryl groups in plasma and bone homogenates. A significant decrease in BMD was observed in O group compared with C group [p=0.015], and a significant increase was observed in OV compared with O group [p=0.003]. When groups were compared with respect to parameters of OS, MDA and NO levels in bone tissue were significantly higher in O than in C [p=0.032, p=0.022] and were significantly lower in OV than in O [p=0.025, p=0.018]. SOD activity was significantly higher in O than in C [p=0.032]. In plasma, MDA activity was significantly higher in O than in C [p=0.022] and NO level was significantly higher in O than in C and OV [p=0.017, p=0.018]. Our results suggest that ovariectomy may produce osteoporosis and OS in females, and vitamin C supplementation may provide alterations regarding improvement in OS and BMD values. We assume that studies including more subjects are needed to make a decisive conclusion about OS-BMD relation
Assuntos
Buscar no Google
Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Osteoporose / Ácido Ascórbico / Compostos de Sulfidrila / Superóxido Dismutase / Catalase / Densidade Óssea / Ratos Wistar / Estresse Oxidativo / Glutationa Peroxidase / Malondialdeído Limite: Animais Idioma: Inglês Revista: Libyan J. Med. Ano de publicação: 2011

Similares

MEDLINE

...
LILACS

LIS

Buscar no Google
Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Osteoporose / Ácido Ascórbico / Compostos de Sulfidrila / Superóxido Dismutase / Catalase / Densidade Óssea / Ratos Wistar / Estresse Oxidativo / Glutationa Peroxidase / Malondialdeído Limite: Animais Idioma: Inglês Revista: Libyan J. Med. Ano de publicação: 2011