De novo malignancy following renal transplantation: As seen in Saudi Arabia

ABSTRACT

To study incidence and type of postrenal transplant de novo malignancy. A total of 730 postrenal transplant patients followed up in our unit for a mean period of 5.3 years was studied retrospectively for development of malignancy. In 48 patients [6.5%] 49 malignancies developed. Of the 48 patients, 36 developed Kaposi's sarcoma and nine patients developed solid tumours [kidney [1], liver [2], thyroid [2], nasopharynx [1], urinary bladder [1], uterus [1], metastasizing adenocarcinoma of unknown aetiology [1]]. Three patients developed non-Hodgkin's lymphoma of diffuse large cell type. The average time from transplantation to development of solid tumours was 7.1 years and for skin tumours was 15.9 months. The paper analyses these findings and compares them with that of the Saudi general population as well as a posttransplant Western population