Effect of naloxone on the recovery from experimental hemorrhage in dogs

ABSTRACT

In the present work experimental haemorrhage was induced and maintained For 30 min. in the first group [8dogs] bled animals were infused with the shed blood; and were considered as a controls group. In this group haemorrhage resulted in a highly significant drop in systolic, diastolic and pulse pressure; while the heart rate was significantly increased. [53.33 +/- 4.08; 32.5 +/- 4.18; 20.8 +/- 22.04; 181.6 +/- 25.6] these average values were maintained for 30 minutes; during which two dogs died. On infusion of the shed blood the alive animals recovered after 5 minutes and gradually the heart rate returned to normal after 30 minutes, while the systolic, diastolic and pulse pressure returned to normal after 45 minutes. In another group of experiments [8dogs] bled animals maintained in the state of shock for 30 minutes were injected with naloxone [1 mg/kg] immediately before infusion of the shed blood. The systolic, diastolic and pulse pressure as well as the heart rate returned to the normal levels within 5 minutes