Effects of L-carnitine and taurine on associated biochemical changes in alloxan induced diabetic rats
EJB-Egyptian Journal of Biochemistry and Molecular Biology [The]. 2011; 29 (1): 99-113
em Inglês
| IMEMR
| ID: emr-117211
ABSTRACT
The aim of the present study was to investigate the beneficial effects of L-carnitine and taurine in healthy and alloxan induced diabetes mellitus in rats. Results showed that diabetic rats had significant increase in the levels of plasma glucose, malondialdehyde [MDA], urea, creatinine and the activity of serum asparate aminotransferase and alanine aminotransferase as compared to normal control rats. While, blood glutathione [GSH] content and erythrocyte superoxide dismutase [SOD] activity were significantly lowered. The elevated plasma glucose, MDA, AST, ALT, urea and creatinine levels of diabetic rats were significantly reduced by treatment for 6weeks with L-carnitine and taurine. In addition, normal healthy rats fed on the balanced diet plus L-carnitine and taurine showed significant increase in blood glutathione [GSH] content and erythrocyte superoxide dismutase [SOD] activity as compared with healthy control. It was concluded that dietary administration of L-carnitine and taurine reduces, delays or even prevent oxidative stress in diabetic rats
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Superóxido Dismutase
/
Taurina
/
Carnitina
/
Estresse Oxidativo
/
Aloxano
/
Glutationa
/
Testes de Função Renal
/
Testes de Função Hepática
/
Malondialdeído
Limite:
Animais
Idioma:
Inglês
Revista:
Egypt. J. Biochem. Mol. Biol.
Ano de publicação:
2011
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