Prognostic and predictive factors of breast cancer among Egyptian women

ABSTRACT

To assess the prognostic as well as the predictive factors among the female Egyptian breast cancer patients to evaluate how much they affect the outcome; being free or had local recurrence or distant metastasis on follow up. From January 1998 to December 2003, 3985 Egyptian women having breast cancer, with their prognostic factors which were age, nodal status and number of affected lymph nodes, tumor size, tumor grade, hormone receptor status, surgical therapy that patients underwent [Modified radical mastectomy versus conservative breast surgery], and whether they received hormonal therapy or not. All data were analyzed retrospectively to detect the 5-year survival rate, using the patients' data sheets and pathology reports that were included. Furthermore, for confirmation the slides were reexamined for the histopathological diagnosis as well as studying their hormonal receptors immunohistochemically. Uni-variant analysis showed that, age lymph nodes [P<0.01] affected the 5- years survival rate significantly. Furthermore, women with >4 affected lymph nodes had more than double fold incidence of having recurrence within the 5- year follow up [RR 2.1; 95% CI; 1.13- 3.99]. Tumor size of more than 2cm increases the risk of recurrence by 18.8 [95%CI; 2.19-161.9]. number of lymph node metastasis, age less than 35 years and tumor size were the most significant prognostic factors affecting the breast cancer behavior among female Egyptian breast cancer patients