[Effects of knotweet or polygonum aviculare herbal extract on proliferation of HeLa cell line]
Medical Journal of Mashad University of Medical Sciences. 2012; 54 (4): 238-242
em Persa
| IMEMR
| ID: emr-117363
ABSTRACT
Cervical cancer is the most common cancer in women living in developing countries. Recently, for treatment of diseases such as cancer, herbal medicine is used as a supplementary. The aim of this study was assessment of anticancerous effects of polygonum aviculare herbal extract on Hela cervical cancer cell line. HeLa cells were cultured in RPMI - 1640 with 10% Fetal Bovine Serum in 5% Co2 and at 37 [degree sign] C in different concentrations [0, 0.005, 0.05, 0.01, 0.025, 0.075, 0.1, 0.125, 0.15, 0.175, 0.2, 0.25, 0.3, 0.35, 0.5, 5 mg/ml] of polygonum aviculare. For assessment of viability of cells, trypan blue staining was performed. MTT assay was used for proliferation detection. Our results showed that in 0.15, 0.20 and 0.35 mg/ml proliferation of HeLa cells decreased according to MTT assay. It was proved that polygonum aviculare had antioxidant component and could be a scavenger of free radical. Because of high production of free radicals in diseases such as cancer, the use of the herbal medicine with high amount of antioxidant could be a supplementary treatment in cancer and other diseases
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Extratos Vegetais
/
Células HeLa
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Neoplasias do Colo do Útero
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Medicina Herbária
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Antioxidantes
Limite:
Feminino
/
Humanos
Idioma:
Persa
Revista:
Med. J. Mashad Univ. Med. Sci.
Ano de publicação:
2012
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