Very severe spinal muscular atrophy [type 0]: a report of three cases
IJCN-Iranian Journal of Child Neurology. 2010; 4 (2): 51-53
em Inglês
| IMEMR
| ID: emr-117733
ABSTRACT
We describe three patients with very severe Spinal Muscular Atrophy [SMA] presented with reduced fetal movement in utero, profound hypotonia, severe weakness and respiratory insufficiency at birth. In all infants, electrodiagnostic studies were compatible with a neurogenic pattern. In genetic studies, all cases had homozygous deletions of exons 7 and 8 of Survival Motor Neuron [SMN] and exon 5 of Neuronal Apoptosis Inhibitory Protein [NAIP] gene. SMA should be considered in the differential diagnosis of reduced fetal movement and respiratory insufficiency at birth
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Atrofia Muscular Espinal
/
Movimento Fetal
Tipo de estudo:
Relato de Casos
Limite:
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
Iran. J. Child Neurol.
Ano de publicação:
2010
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