[Comparison of the toxic effects related to experimental induction of diabetes by Alloxam and Strepytozotocin in rats]

ABSTRACT

Both Alloxan and Streptozotocin [STZ] are selective substances used to induce experimental diabetes, because they have an important property to damage beta-cells that secrete insulin in Pancreas. But their use has some problems; they have toxic effects on important body organs and also cause some necrosis in tissue. The aim of this study was to clarify the best way of administration, so we examine the acute way which includes giving a single high dose of both the previous materials. Indeed, we also examine a gradual way that includes giving the substances in repeated low doses with intervals last for several days. We measured the changes of weight, the elevation in blood sugar and the mortality for both previous ways. Indeed, a histological study was performed for important body's organ following the administration of the mentioned materials in the gradual way. The findings indicated clearly that the gradual way for both Alloxan and STZ was more safe and effective than acute administration. STZ was best from Alloxan especially in the gradual way concerning the inducing of diabetes and the low mortality. According to these results we recommend to use STZ with the gradual way in the researches that require experimental diabetic animals