Effect of calcium channel blockers on the hemodynamic changes of hyperthyroidism

ABSTRACT

To study the effect of Ca[+2] channel blockers on hemodynamic changes in hyperthyroid patients, 14 patients were classified in to group I [seven patients received verapamil for one month] and group 2 [seven patients received both verapamil and carbimazole for one month]. Verapamil controlled the hemodynamic changes such as pulse rate, hyperkinetic apex and ejection systolic murmur in the majority of patients. The EGG showed positive changes under verapamil therapy alone, but relative to the combined effect with carbimazole, these changes were incomplete. The peripheral blood flow was corrected enermously by verapamil but its combination with carbimazole made the blood flow nearer to the control value than its action alone. Verapamil as a calcium channel blocker, controlled significantly blood pressure, pulse pressure, mean arterial blood pressure and improved many cardiac complications. verapamil also improved the hemodynamic state in one patient who had had a bronchial asthma where propranolol is contraindicated. Verapamil can be regarded as a good therapeutic tool in prevention of cardiac injury secondary to persistent ischaemia reported to be common in thyrotoxicosis