Effect of acute central administration of neuropeptide y [NPY] on gonadotropic ovarian axis in adult female rats

ABSTRACT

Eighteen female albino rats were used in this study. They were subdivided into 3 groups each of 6 animals, first group is formed of normal control, injected intra cerebroventricularly [ICV] with normal saline. Second group [low dose NPY group] where animals were injected with 30 microg/kg NPY by the ICV route, the 3rd group [high NPY group] the animals were injected by 70/microg/kg NPY by the same route. Two hours later after injection, serum level of lutienizing hormone [LH], follicle stimulating hormone [FSH], oestrogen and progesterone were estimated for all the 3 groups. The study revealed a significant increase in FSH, significant decrease of LH and non significant change in oestrogen and progesterone levels in animals injected with low dose of NPY. High NPY injected animals showed significant increase in FSH and oestrogen, significant decrease in LH, non significant change in progesterone levels. These results suggest that NPY may play a direct role in control of gonadotropic ovarian hormonal levels