Some hepatotoxic and reproductive effects of vincristine sulphate and doxorubicin chloride in normal and liver damaged male rats

ABSTRACT

Vincristine sulphate [I] and doxorubicin hydrochloride [II] in large doses for short time increase significantly serum liver enzymes in both young and aged rats. Smaller doses from each and both in combination failed to affect liver enzymes of young rats, also smaller doses from all treatments for 21 days failed to affect liver enzymes of young and liver damaged rats. Smaller or larger doses for short or long periods significantly affected liver enzymes of aged rats. [I] in large or small doses did not affect the sperm quality or internal organs, while [II] significantly affected sperm quality when given alone or with [I] in all conditions