effect of adrenoreceptor blocking agents on portal hypertension in heptosplenic schistosomiasis

ABSTRACT

There was significant reduction of intrasplenic pressure after oral propranolol, atenolol and prazosin. Significant difference was found between propranolol and each of atenolol and prazosin, but no significant difference was found between atenolol and prazosin in reducing intrasplenic pressure. Propranolol seems to be the drug of the first choice. Atenolol and prazosin may be saved when other conditions, in which propranolol could not be used, to exist, for example bronchospastic disorders, diabetes mellitus and severe impairment of liver functions