Biochemical studies on the effect of some schistosomicidal drugs on the production of the bladder carcinogen xanthurenic acid

Male Swiss albino mice were studied to demonstrate the in vitro effect of two antimonial antibilharzial drugs [anthiomaline and Astiban] and two non-antimonial drugs [Vansil and Bilarcil] on the activity of vitamin B-dependent 3-hydroxy kynureninc aminotransferase enzyme. The effect of increasing pyridoxal phosphate concentration on the enzyme activity was also studied. The results revealed that both antimonial and non-antimoial drugs inhibited the B-dependent 3-hydroxy kynurenine aminotransferase in vitro. Increasing the concentration of pyridoxal phosphate could not completely overcome the inhibitory effect of these drugs. Moeover, there was no interaction between the used antibilharzial drugs and pyridoxal phosphate in vitro. Also, the direct interaction of the drugs with the enzyme is not likely. Therefore, the inhibitory efect o the studied anti-bilharzial drugs on the activity of B-dependent 3-hydroxy kynurenine aminotransferase enzyme could lead to the accumulation of the bladder carcinogenic compound 3-hydroxy kynurenine