Glycosylated hemoglobin in relation to serum immunoreactive insulin and plasma glucose in patients with chronic renal failure on maintenance hemodialysis

ABSTRACT

The present study was carried out on 20 patients with chronic renal failure undergoing maintenance hemodialysis and six healthy non-hospitalized control individuals. The aim of this work was to study, the glycosylated hemoglobin in relation to serum immunoreactive insulin and plasma glucose levels in patients with chronic renal failure and the effect of one month regular hemodialysis on these value. Before hemodialysis glycosylated hemoglobin is elevated in uremic patients, but cannot be used as an indicator of carbohydrate metabolism because it declines to normal level with improvement of uremic state with hemodialysis. Also, fasting serum insulin level is high in uremic patients, but hemodialysis and improvement of azotemia reduced basal serum insulin level