Neuroleptic malignant syndrome, an underestimated complication of antipsychotics

ABSTRACT

Neuroleptic malignant syndrome [NMS] was previously reported to be a rare complication of antipsychotic drugs. It was detected in 4 out of 482 psychotics. Butyrophenones [haloperidol] showed the highest association with the development of the syndrome, especially when given parenterally. The syndrome developed regardless of the antipsychotics was following by spontaneous recovery. Anticholinergics are not recommended for treatment of the syndrome