immunohistochemical study on the histogenesis of granular cell tumor

ABSTRACT

The presence and distribution of S-100 protein, desmin and alpha-1- antichymotrypsin were investigated in ten cases of granular cell tumor using the peroxidase-antiperoxidase method. The granular cells of all cases were negatively stained with anti-desmin and anti-alpha-1-antichymotrypsin antisera. On the other hand, they were positively stained with anti-S-100 protein antiserum. These results supported the concept of the neurogenic origin of the granular cell tumor