Effects of some premedicant agents on pulmonary function tests

ABSTRACT

This work was done on 60 patients, all subjects were free of overt cardiorespiratory disease. The patients were divided into four groups [15 in each]. The first group received 10 mg diazepam i.m. The second group were given morphine sulfate 10 mg i.m. The third group received 100 mg meperidine HCl, i.m. and the last group received 2 mg buterphanol. All drugs were given one hour preoperatively. Statistical analysis showed that diazepam caused significant reduction of respiratory rate, tidal volume, [P <0.05] and nonsignificant reduction of all other pulmonary function tests. Morphine, meperidine and buterphanol produced significant reduction of RR, VT, MVV and PEFR [P <0.05], meperidine and buterphanol produced also significant reduction of FEFR and MEFR [P <0.05]