effects of metoclopramide and clonidine hydrochloride premedication on intraocular pressure

ABSTRACT

Thirty adult patients classified into three equal groups were studied to evaluate the effect of premedication on intraocular pressure [IOP]. In group I [control group], atropine premedication was not accompanied by significant changes in IOP. In group II [metoclopramide group] where metoclopramide was given in addition to atropine, premedication was accompanied by significant increase in IOP, while in the third group [clonidine group] where clonidine CHL was given in addition to atropine, there was a significant decrease in IOP after premedication. Following intravenous induction with thiopentone sodium, there was a significant IOP reduction in the three groups. The reduction was significantly less in metoclopramide group than in control and clonidine groups. No significant changes in IOP was observed in the three studied groups after administration of vecuronium. In the three studied groups, laryngoscopy and endotracheal intubation were accompanied by a significant increase in IOP after one and two minutes. This rise was significantly less in clonidine groups than in control and metoclopramide groups. By the fifth minute following laryngoscopy and intubation, the three groups showed significant IOP reduction