Afterload reduction with captopril in chronic aortic regurgitation
Bulletin of Alexandria Faculty of Medicine. 1994; 30 (3): 597-603
em Inglês
| IMEMR
| ID: emr-120966
ABSTRACT
The chronic hemodynamic effects of captopril were assessed in 22 asymptomatic patients with a moderate to severe isolated aortic regurgitation [AR] before and 3 months after administration of captopril [50-100 mg/day]. Supine heart rate decreased from 81.8 +/- 13.9 to 74.8 +/- 11.3 beats/min. [P <0.01], supine systolic blood pressure from 143.16 +/- 11.07 to 118.18 +/- 9.2 mmHg [P <0.001], mean wall stress from 796.77 +/- 162.78 to 655.6 +/- 148.69 Kdyn/cm2 [P <0.001] and septal thickness from 10.5 +/- 2.26 to 9.9 +/- 2.06 mm [P <0.05]. Left ventricular [LV] end-systolic and end-diastolic volumes, ejection fraction, shortening, fractional LV posterior wall thickness and LV mass did not change significantly. The degree of AR did not change significantly during the 3-month follow-up period. Captopril in a dose of 50-100 mg daily improves left ventricular afterload in asymptomatic patients with chronic AR, and a longer period of follow up is required to show its effect on LV mass and the severity of aortic regurgitation
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Insuficiência da Valva Aórtica
/
Determinação da Pressão Arterial
/
Função Ventricular Esquerda
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Bull. Alex. Fac. Med.
Ano de publicação:
1994
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