Serum matrix metalloproteinase-2 in patients with chronic hepatitis C and hepatocellular carcinoma
Medical Journal of Cairo University [The]. 2005; 73 (Supp. 2): 137-44
em Inglês
| IMEMR
| ID: emr-121208
ABSTRACT
The present study aimed to examine the possible involvement of matrix metalloproteinase-2 [MMP-2] in the development of liver diseases caused by HCV infection. The serum activities of MMP-2 enzyme were studied by enzyme immunoassay [EIA] in sera from patients with HCV and HCC on the top of HCV. This study included 46 Egyptian patients presenting with either chronic hepatitis C infection [HCV] or hepatocellular carcinoma [HCC]. Eighteen subjects were included as a control group. The serum levels of MMP-2 were found to be significantly higher in both patient groups as compared with the control group. However, there was no significant difference between HCV and HCC patient groups. There was a significant positive correlation between the serum levels of MMP-2 and the severity of the liver disease as shown in its significant relationship with other liver function tests, but no correlation was found with alpha fetoprotein [ALP] levels
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Alfa-Fetoproteínas
/
Carcinoma Hepatocelular
/
Metaloproteinase 2 da Matriz
/
Testes de Função Hepática
/
Neoplasias Hepáticas
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. J. Cairo Univ.
Ano de publicação:
2005
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