Karyo type analysis in chronic myelogenous leukemia Athree year experience at the American university of Beirut medical center

ABSTRACT

We report the results of karyotype analysis on cases referred to our laboratory for chronic myelogenous leukemia [CML] over a period of three years. A total of 68 patients were referred and a karyotype was successfully obtained in all cases except one. Thirty one percent of cases were found to have a normal karyotype, 58.5% were Philadelphia [ph1] positive while 10.5% of cases had chromosome abnormalities other than ph1. among the ph1 positive cases, 92% had the standard translocation [9;22], 7.7% had a variant translocation and 12.8% had additional chromosome abnormalities. Our results are compared to those generally reported in the literature and the comparisons are discussed