[ therapeutic effects of oral administration of garlic extract and tablet on experimentally lead acetate poisoning in mouse]

ABSTRACT

To study the therapeutic effects of garlic extract and tablet on lead poisoning in mouse. Experimental study. Eighty mature male mice with 22-25g body weight. Mice were divided into 8 groups of 10 mice each. All groups received lead acetate [5mg/kg of bady weight] for 21 weeks and after then treated daily for another 4 weeks as follows group A1, 500mg/kg fresh garlic; group A2, 250mg/kg fresh garlic; group A3, 125mg/kg fresh garlic; group B1, 1/4 Garlet tablet per kg body weight [Eq. to 500 mg fresh garlic]; group B2, 1/8 Garlet tablet per kg body weight [Eq. to 250 mg fresh garlic]; group B3, 1/16 Garlet tablet per kg body weight [Eq. to 125 mg fresh garlic]; group C, 5mg/kg lead acetate and group D did not received any thing in both the first 4 and the second 4 weeks. These results showed that daily administration of fresh garlic [preferably 250-500 mg/kg] or Garlet tablet [1/4 of one garlet tablet per kg body weight] can have therapeutic effects on mice with chronic lead administration. Result showed that garlic and garlet tablets [in a lower grade] have the ability to reduce the lead residues in soft tissues as well as bone in chronic lead poisoned mouse. So, it can be concluded that garlic can be used for lead poisoning therapy in mouse and probably in human and other animals. Moreover, fresh garlic or garlet tablet in aforementioned dose could be used in areas with lead pollution