Determination of diosmin in pharmaceutical formulations using fourier transform infrared spectrophotometry

ABSTRACT

A Fourier transform infrared [FT-IR] spectrometric method was developed for the rapid, direct measurement of diosmin in different pharmaceutical drugs. Conventional KBr- spectra were compared for best determination of active substance in commercial preparations. The Beer-Lambert law and two chemometric approaches, partial least squares [PLS] and principal component regression [PCR+] methods, were tried in data processing