Correlation of plasma endothelin-1 levels with pulmonary hypertension after inhaled nitric oxide therapy
JAMC-Journal of Ayub Medical College-Abbotabad-Pakistan. 2009; 21 (3): 106-110
em Inglês
| IMEMR
| ID: emr-123296
ABSTRACT
Variable response to inhaled nitric oxide [iNO] therapy in patients with mitral stenosis [MS] having pulmonary hypertension [PH] has been documented in early studies. The objectives of this study were to measure plasma Endothelin-1 [ET-1] levels in those patients and to correlate them with pulmonary vascular indices after iNO therapy. It was Quesi-experimental study. Thirty patients with mitral or mixed mitral and aortic valve disease with severe pulmonary hypertension and vascular indices and cardiac output were recorded. After the surgery, 10-20 ppm iNO was administered for 1 hour and all the parameters were again recorded. Patients were grouped into responders and non responders on the basis of% reduction in Pulmonary Vascular Resistance [PVR] after iNO therapy. Plasma ET-1 levels were measured in both groups by ELISA before and after the iNO therapy. Paired sample t-test was used to compare mean values for significance. The correlations between variables were then calculated by using Pearson's coefficient. The plasma ET-1 levels were very high in all patients. They reduce in responders after iNO therapy; non-responders paradoxically showed significant increase in the levels of ET-1 after iNO therapy. Moreover, a positive correlation was observed in plasma ET-1 levels and post operative levels of PVR. The correlation of changes in PVR and plasma ET-1 is a key mediator of poor response in PH secondary to MS, after iNO therapy
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Administração por Inalação
/
Endotelina-1
/
Estenose da Valva Mitral
/
Óxido Nítrico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Ayub Med. Coll.-Abbotabad-Pak.
Ano de publicação:
2009
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