Effect of unilateral ureteral obstruction on plasma and kidney tissue sodium, potassium levels and on renal sodium-potassium adenosine triphosphatase activity in rats

ABSTRACT

The present study was carried out on 20 male albino rats divided into two groups. Sham operated control [10 rats] in which the ureter was visualized but not ligated. The other group [10 rats] the animals were exposed to unilateral obstruction for 48 hours after which blood samples were collected, and both kidneys in each rat were removed. In the unilateral ureteral obstruction group, significant decrease of kidney tissue levels of Na + and K + as well as significant decrease of Na + - K + ATPase activity in kidney cortex and outer medulla tissue homogenate with nonsignificant changes in plasma Na + and K + levels were detected as compared to contralateral kidney and sham operated control group. While, in the contralateral kidney, cortex and outer medulla homogenate and insignificant changes of kidney tissue K + were detected as compared to sham operated control group. Results were fully discussed