Small choroidal melanoma with monosomy 3
MEAJO-Middle East African Journal of Ophthalmology. 2010; 17 (3): 268-269
em Inglês
| IMEMR
| ID: emr-123603
ABSTRACT
To report a patient with small juxtapapillary choroidal melanoma with chromosome 3 monosomy treated with I[125] plaque and transpupillary thermotherapy [TTT]. A 64-year-old Caucasian male presented with painless blurred vision of the left eye. Ocular examination disclosed a small juxtapapillary choroidal melanocytic tumor with overlying subretinal fluid and orange pigment. Ultrasound showed an elevated choroidal mass of 2 mm thickness with low reflectivity on A-scan and hollowness on B scan, consistent with a small choroidal melanoma. The patient was treated with plaque I[125] radiotherapy combined with one session of TTT. Genetic testing of the tumor cells obtained by fine needle aspiration biopsy showed chromosome 3 monosomy. At 1 year after treatment, the tumor was regressed with resolution of subretinal fluid and 20/40 visual acuity. A small choroidal melanoma can manifest monosomy of chromosome 3, a known predictive factor for the development of systemic metastasis
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Cromossomos Humanos Par 3
/
Neoplasias da Coroide
/
Olho
/
Monossomia
Tipo de estudo:
Relato de Casos
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Middle East Afr. J. Ophthalmol.
Ano de publicação:
2010
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