[Investigation of diagnostic values of hsCRP in pleural fluid for differentiation tuberculosis and malignant pleural effusion pulmonary and TB research center]

ABSTRACT

Pleural effusion is one of the most common and important complications in pulmonology. When the absorption of pleural fluid is less than its secretion, effusion happens and diagnosis between TB and malignant pleural fluid is important. C reactive protein with high sensivity[hsCRP] is secreted by tissue when inflammations is present. The aim of this study was hsCRP evaluation could help to differentiate between TB and malignant pleural effusion. 100 patients with TB or Malignant pleural effusion who referred to Emam Reza hospital, Mashhad in 2009 underwent thoracocentesis; then hsCRP with photometry methods were analyzed. All data were analyzed by SPSS 11 and cutoff point for hsCRP with ROC curve was found. Mean age was 53.41 years 19.63 SD. Mean concentration of hsCRP was 9.53 [mg/lit] with SD 5.78 [mg/lit]. hsCRP concentration in TB group was 13.6 +/- 5.6 and in malignant pleural effusion group was 6.00 +/- 3.93 [mg/lit]. They had significant different with statistical analysis [P<0.001]. Sensitivty of hsCRP to differentiate between TB and malignancy with cutoff point of 8.35[mg/lit] is 92% and specificity is 78%. They had significant different with statistical analysis [P<0.001]. hsCRP cloud help us to differentiate between TB and malignant pleural effusion