Topical mitomycin-C versus subconjunctival 5-Fluorouracil for management of bleb failure

To compare the efficacy and safety of topical mitomycin C [MMC] drops with that of subconjunctival 5-fluorouracil [5-FU] injections for management of early bleb failure after trabeculectomy or combined phacoemulsification and trabeculectomy with posterior chamber intraocular lens implantation [PT+PCIOL]. In a randomized comparative study, 37 eyes of 37 patients with impending early bleb failure received MMC 0.02% eye drops for 2 or 4 weeks [19 eyes] or subconjunctival 5-FU injections, 5 mg per dose [18 eyes]. Complete success was defined as 5 < IOP