Correlation between antithrombin III and glucose intolerance, type of diabetes, diabetic nephropathy and serum triglyceride level

ABSTRACT

Oral glucose tolerance test OGTT] and the serum levels of Tiglycerides [TG] and antithrombin III [AT III] were determined in 33 diabetic and 8 normal subjects. AT III was determined by radial immunodiffusion technique. The present results denote that the level of AT III in diabetics is not significantly different from the normal controls. Also, it shows that the level of AT III in diabetics is not affected by elevation of the serum TG or by increased impairement of glucose tolerance. Moreover, AT III in diabetics with mild proteinuria was not significantly different from that in patients without proteinuria, nor patients with diabetes of longer than 5 years duration have a different level of AT III than those with diabetes of shorter duration. Juvenile-onset diabetics [JOD] tend to have a higher AT III level as compared with the maturity-onset diabetics [MOD], though the difference was statistically nonsignificant. These results were discussed in relation to the possible role of AT III in the pathogenesis of diabetic vascular disease