Effects of ambilhar on the pregnant female rats and their neonates

ABSTRACT

The present work was undertaken to study the effect of ambilhar [antibilharzial drug] on the pregnant female rats and their necnates. Ten pregnant female rats were used in this work. They were divided into five experimental and five control animals. From the eighth till the fourteenth day of gestation, the experimental animals were given a daily oral dose of 6 mg Niridazole [ambilhar] dissolved in normal saline. All the rats were allowed to deliiver. The mothers and their neonates of both the experimental and the control groups were killed on the first day of delivery. The heart, liver, kidney and spleen were tajen for the histological and histochemical studied. Administration of ambilhar were followed by marked degenerative changes in the organs under investigation. Thansplacental passage was also proved in the present study as many histopathological changes were observed in the fetal organs. There were also a decrease in the activity of the alkaline phosphatase enzyme and the reaction of PAS. The significance of these findings was discussed