Pharmacological study of a new synthetic potential diuretic

ABSTRACT

A new synthetic disulfamyl compound with pyrimidine nucleus was studied for its oral diuretic action in both rats and dogs and it was found to have directic activity comparable to that of hydrochlorothiazide, but with the advantage of less augmentation of potassium excretion. Acute toxicity studies revealed that this compound has exceedingly high oral and intraperitoneal LD[50] [>8000 mg/ Kg and 325.6 mg/ Kgm] respectively. Again the subacute toxicity studies confirmed the very low toxicity of this compound as is induced no significant changes in all the parameters studied and was devoided of the hypokalaemic effect produced by hydrochlorothiazide. Pharmacological in vivo and in vitro studies pointed to the potential parasympathomimetic activity of the test compound