Association of the co-stimulatory molecules polymorphisms with CMV infection in liver transplant recipients
International Journal of Organ Transplantation Medicine. 2011; 2 (4): 171-177
em Inglês
| IMEMR
| ID: emr-124397
ABSTRACT
Co-stimulatory molecules play a critical role in regulating T-cell function during CMV infection after liver transplantation. To investigate the relationship between the polymorphisms of the co-stimulatory genes and the susceptibility to CMV infection after liver transplantation. Single nucleotide polymorphisms [SNPs] in PD-1 gene [PD1.1 A/G, PD1.3 A/G, PD1.9 C/T] ICOS [-693 A/G, 1720 C/T], CTLA-4 gene [-318 C/T, 1722 T/C, 1661 A/G, 49 A/G] and CD28 [+17 C/T] were analyzed by PCR-RFLP in 70 liver transplant patients. CMV infection was determined in these patients by antigenemia test. CTLA-4 49G showed significant association with CMV infection [p=0.03, OR=3.82, 95% CI 0-3.5; p=0.01, OR=004, 95% CI 0-1.3]. G and T alleles in CTLA-4 gene [-318 C/T and 1661 A/G] [p=0.03, OR=0, 95% CI 0-3.5; p=0.01, OR=0.04, 95% CI 0-1.3] were significantly higher in CMV-infected rejector group. CTLA-4 have significant role in CMV pathogenesis and rejection among CMV-positive liver transplant patients
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
DNA
/
Reação em Cadeia da Polimerase
/
Transplante de Fígado
/
Polimorfismo de Nucleotídeo Único
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Citomegalovirus
/
Genótipo
/
Rejeição de Enxerto
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. J. Organ Transplant. Med.
Ano de publicação:
2011
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