Fibrin degradation products [FDP] in urinary bladder transitional cell carcinoma [TCC] as a marker of its invasiveness

ABSTRACT

Urinary FDPs were estimated in 15 patients with superficial TCC, 15 patients with deep TCC and in 10 healthy controls. Significantly higher FDPs levels were detected in the tumor group. FDPs in deep tumors were significantly higher than in superficial ones. The FDPs level showed a positive correlation with tumor grade and stage. Comparison between FDPs and urine cytology displayed better sensitivity for FDPs in tumor diagnosis. FDPs may be used as a marker of tumor invasiveness