[Effects of vitamin E supplementation on activity of serum paraoxonase, SOD, GPX enzymes and lipid profiles in beta major thalassemia patients]
Journal of Gorgan University of Medical Sciences. 2012; 13 (4): 35-43
em Persa
| IMEMR
| ID: emr-124469
ABSTRACT
In pathogenesis of beta major thalassemia, tissue damage is occurring due to oxidative stress. The present study was designed to evaluate the effects of vitamin E supplementation on serum Paraoxonase, SOD, GPX enzyme activity and lipid profiles in beta major thalassemia patients. In this clinical tiral study, Sixty [25 males, 35 females] beta major thalassemia patients with age >/= 18 years who had criterias to enter the study, were selected randomely in two groups. The patients in interventional group, vitamin E at a dose of 400 mg/day were given for three months, with no supplementations in control group. The enzyme activities of paraoxonase, SOD, GPX and lipid profiles [LDL-c, HDL-c, triglyceride, total Antixidant Capacity] were measured prior and after 3 months in both case and control groups. Data analyzed by using paired t-test. Significant increases in serum levels of vitamin E, Paraoxonase activity, HDL cholesterol [P<0.001], BMI [P = 0.001] and a significant reduction in GPX activity [P<0.05] were observed in cases compared to controls. The vitamin E supplementation may be useful in reducing oxidative stress and lipid profiles in beta major thalassemic patients
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Superóxido Dismutase
/
Triglicerídeos
/
Talassemia beta
/
Estresse Oxidativo
/
Arildialquilfosfatase
/
Glutationa Peroxidase
/
Lipídeos
/
HDL-Colesterol
/
LDL-Colesterol
/
Antioxidantes
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Persa
Revista:
J. Gorgan Univ. Med. Sci.
Ano de publicação:
2012
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