comparative study to evaluate the role of alpha tocopherol in pregnancy induced hypertension

ABSTRACT

To assess the role of alpha tocopherol in Pregnancy Induced Hypertension [PIH] by comparing pregnancy induced hypertensive patients on routine anti-hypertensive measures with pregnancy induced hypertensive patients on alpha tocopherol plus routine antihypertensive measures. Retrospective Randomizing Study. This study was conducted at the Department of pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi from April 2004 to Sept. 2004. Two groups each comprising of 25 pregnancy induced hypertensive females, age ranging from 18-40 years were studied in this study. Changes in systolic and diastolic blood pressure were assessed from 24-28 weeks of pregnancy and were followed at every 15 days till the time of delivery in Control Group-I [G-I] and Test Group-II [G-II]. On day-0 systolic blood pressure on average showed higher value in G-II compared to G-I. On day 30, 60 and day final, the mean systolic blood pressure showed lower values in G-II although the difference was found statistically insignificant. When diastolic blood pressure studied, it showed on the average same readings for G-I and G-II on day-0. On day 30, day 60 and day final, it also showed statistically insignificant difference between G-I and G-II with higher mean diastolic blood pressure in G-I. Alpha tocopherol exerted better effect on systolic and diastolic blood pressure in test group when compared with control group