Study of INF-gamma and IL-6 in patients with Helicobacter pylori

ABSTRACT

Helicobacter pylori evade host immune defenses and causes chronic gastritis. Immunity against intestinal pathogens is largely mediated by dendritic cells, yet the role of dendritic cells in acute H pylori infection is largely unknown. The current study was to determine the serum/plasma levels of inflammatory cytokines IL-6 and TNF-alpha in H pylori patients and explain the correlation with disease state, helicabacter pylori Ab IgG and 1gM and urea Breath test. We examined the levels of serum cytokines IL-6 and INF-gamma in 50 patients. Mean serum/plasma levels of IL-6 and INF-gamma in H. pylori patients were significantly higher than those in the healthy controls [P<0.05]. There was a statistically significant correlation between IL-6 levels and INF-alpha in group of positive and negative, IgM. levels of IL-6 and INF-gamma can be used as important parameters for clinical diagnosis and follow up of Helicobacter pylori cases. CRP and ESR is a useful marker ongoing infection but there is Correlation with disease state