[Investigation on the levels of IGF-I receptor and IGF-I binding protein I in the brain of insulin resistant rats]
IJEM-Iranian Journal of Endocrinology and Metabolism. 2010; 11 (6): 707-712
em Persa
| IMEMR
| ID: emr-125363
ABSTRACT
There is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor [IGF-I] to transducer the signals in different areas of the brain. In this article we aimed at investigating whether the expression of IGF-I receptor and IGF-I binding proteins [IGFBP1] is changed in the brain of the diabetic animal model. To induce insulin resistance, adult wistar rats were fed with fructose in their drinking water [10%]. The expression of IGF-I receptor and its binding protein were examined immunohistochemically. Our findings demonstrated that the expression of IGF-I receptor and IGF-I binding protein were not changed in different areas of the brain in insulin resistant rats, compared to those in the control rats. The unchanged expression levels of IGF-I and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant brain, further investigations are to clarify the issue
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Encéfalo
/
Resistência à Insulina
/
Ratos Wistar
/
Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Diabetes Mellitus Tipo 2
Limite:
Animais
Idioma:
Persa
Revista:
Iran. J. Endocrinol. Metab.
Ano de publicação:
2010
Similares
MEDLINE
...
LILACS
LIS