Morphological spectrum of chronic hepatitis [C] infection: experience at foundation university medical college and Fauji foundation hospital Rawalpindi

ABSTRACT

To determine the morphological patterns of HCV related liver disease in our set up. 164 routinely processed liver biopsies were assessed and scored for grading [necro-inflammatory changes] and staging [fibrosis] using modified Knodell HAI scoring system. Our patients were mostly females and maximum cases were in 4[th] and 5[th] decades. Mild portal inflammation was seen in 78% and moderate in 20% cases. Piecemeal necrosis was mild in 76% while moderate in 15% cases. HAI grades ranged from mild [161 cases] to moderate [03 cases]. Fibrous portal expansion/short fibrous septae were seen in 35[21.3%] cases. HCV related lived disease is mild in our set up and a long term follow up of these cases is required to assess the progression of disease