Association of c-reactive protein as an inflammatory marker with the glycaemic status of the alloxan treated diabetic rats
Pakistan Journal of Pathology. 2009; 20 (3): 94-98
em Inglês
| IMEMR
| ID: emr-125572
ABSTRACT
To measure the level of C-reactive protein and find its association with the glycaemic status [fasting plasma glucose, glycosylated haemoglobin] of metabolically normal and diabetic albino rats. Total 60 Albino rats were included into [metabolically normal rats n=30; diabetic rats n =30]. Plasma glucose levels were determined by using glucose oxidase method while determination of total Hb and glycosylated hemoglobin [HbA[1]c] was done by diagnostic kit that uses weak cation-exchange resin to bind Hb. The% HbA[1]c was determined by measuring the absorbance at 415 nm of the glycosylated hemoglobin fraction and the total hemoglobin fraction. The ratio of the two absorbances gave the% of HbA[1]c. C-reactive protein was measured by the ELISA kit. Significant difference was found in the values of fasting glucose, of the normal and diabetic groups [p<0.05] but no significant difference was present in the values of HbA[1]c of both groups. There was no significant difference in the values of C-reactive protein of the normal and diabetic groups. Short duration hyperglycemia has no role in producing inflammation and raising the levels of bioinflammatory marker C-reactive protein
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos
/
Glicemia
/
Hemoglobinas Glicadas
/
Biomarcadores
/
Mediadores da Inflamação
/
Diabetes Mellitus Experimental
/
Aloxano
Limite:
Animais
Idioma:
Inglês
Revista:
Pak. J. Pathol.
Ano de publicação:
2009
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