[Graft survival rate of renal transplantation in diabetic patients, Namazi hospital transplant center, Shiraz, Iran [1999-2009]]

ABSTRACT

In many countries around the world, diabetic nephropathy is the most common causes of renal transplantation and dialysis. One third of diabetic patients suffer from kidney diseases which, in turn, considerably increase mortality rates and treatment costs. The aim of this study was to compare graft survival rate in diabetic and non-diabetic patients in the Shiraz Namazi Hospital Transplant Center, during the years 1999 to 2009. This study was a retrospective cohort study that investigated graft survival rate among diabetic patients who had undergone kidney transplant and compared it with that of non-diabetic patients, in the Transplant Center of Shirza Namazi Hospital. The Kaplan-Meier method was used to calculate the survival rate and Log-rank test was applied to compare survival curves. Furthermore, to model the factors affecting survival rate, Cox proportional hazard model was implemented. The results of the study revealed that the average follow-up period of patients was 48.15 +/- 31.05 [range 3.07- 118.03] months. The estimated 9-year graft survival rates among diabetic and non-diabetic patients were 84.2% and 85.7%, respectively. Moreover, using Cox proportional hazard model, it was found that the age of a donor <40 years, is an effective factor for higher graft survival rate in diabetic patients. Based on the results of this study, we observed that there was no significant difference between kidney transplant survival rate in diabetic and non diabetic patients. This treatment method can hence be a good option for patients with diabetic nephropathy