Impact of experimental duel infections with schistosoma mansoni and echinoccocus granulosus on hepatic histopathology
Journal of the Egyptian Society of Parasitology. 2007; 37 (3): 1175-1188
em Inglês
| IMEMR
| ID: emr-126491
ABSTRACT
Experimental duel infection with S.mansoni and E. granulosus was induced in mice to determine their effect on serum nitric oxide [NO] level and accordingly on the sequences of histopathological lesions affecting the liver. The results showed that serum NO level was significantly increased [p = 0.05] in mice infected with both parasites [GI] in comparison to either S.mansoni [GIV] or E. granulosus [GV]. The NO elevation on hepatic pathological lesions of both diseases showed a marked reduction of granuloma size with absence of concentric fibrosis in GI as early as 4 weeks of concomitant infection as compared to GIV. In spite of the significant increase of NO level when E. granulosus infection induced in late stages of schistosomiasis [GsII and III], yet granuloma size was not suppressed. Also, there was absence or death of hydatid cyst in mice [GI] compared to E. granulosus [GV]. So, the duel infection with the two parasites affected serum NO level and hepatic hisotopahtology, by ameliorative or deteriorative effects, according to duration of infection with either
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Equinococose
/
Histologia
/
Fígado
/
Camundongos
/
Óxido Nítrico
Limite:
Animais
Idioma:
Inglês
Revista:
J. Egypt. Soc. Parasitol.
Ano de publicação:
2007
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