[ preventative role of sesame oil on phlebitis induced by anti-neoplastic agents]

ABSTRACT

Phlebitis is an inflammatory response to intravenously injected chemotherapy drugs and the reported incidences about 70% among colorectal cancer patients. The purpose of this study was to determine the effect of external use of Sesame Oil [SO] in prevention of chemotherapy-induced phlebitis. This randomized controlled clinical trial was performed on 60 patients with colon or rectum cancer, who randomly divided in two equal, control and intervention groups. This protocol was used 10 drops of SO every 12 hours, two times a day, from the first day of chemotherapy up to the four tenth day, whereas control group received nothing. Data tools included a bipartite questionnaire [demographic Q, clinical Q and Infusion Therapy scale] for measurement of phlebitis. The incidence of phlebitis in intervention group were significantly lower than that in control group [p<0.05]. Kaplan-Meier survival analysis showed that the median survival was Less than 4 days in the intervention and 8 days more in the control. In addition, there was statistically significant difference between grade and incidence of chemotherapy-induced phlebitis with SO and control group [p<0.05]. This study shows that external use of SO is effective and well tolerated for prophylaxis from chemotherapy- induced phlebitis. Therefore, it can be suggest as a selected Prevention method for reducing the complication