Vasodilators versus lansoprazole in prevention of ethanol induced gastric ulcer

ABSTRACT

Peptic ulcer is a condition result from imbalance between the erosive effect of acid and pepsin and mucosal defense mechanism in the stomach and may be correlated with vasodilators. Forty two healthy albino male rats weighing [180-200] gram were involved in this study. The animals were allocated to six groups. Each group was given one of the following drugs Lansoprazole, amlodipine, amiodarone, carvedilol and distilled water as control. After 5 days of treatment with these agents, ethanol 95% was administered orally after one hour of the last dose of these agents. Animal were sacrificed after one hour later. The main parameters used in this study were ulcer preventive index, free radicals, changing of serum electrolytes. Ethanol in high concentrations was found to be highly ulcerogenic agent with ratio of 100% when administered orally in rat The preventive index [PI] of these drugs equal 86.95,96.99and 83.63 for amlodipine, amiodarone andcarvedilol respectively in comparing with lansoprazole 99.09. All the tested drugs and lansoprazole produced highly significant change in free radicals of the gastric tissue decreasing MDA levels andincreasing GSH levels. Some of serum electrolytes were significantly changed by the tested drugs. Amlodipine, amiodarone and carvedilol proved to have gastro-protective activity against ethanol induced gastric ulcer and the possibility to be used for patients with peptic ulcer or cardiovascular problems with peptic ulcer