Is anti-cyclic citrullinated peptide antibody a good value biomarker for Alzheimer disease?
IJPM-International Journal of Preventive Medicine. 2013; 4 (Supp. 2): 201-204
em Inglês
| IMEMR
| ID: emr-127453
ABSTRACT
Alzheimer's disease [AD] is one of the most important neurodegenerative disorder. Anti-cyclic citrullinated peptide [anti-CCP] may all be involved in the development of vascular disease such as AD. The aim of this study is detection of seropositivity for anti-CCP antibody in AD patients. In our study, 30 patients with AD and 29 healthy controls [age and-sex matched] were recruited. Homocysteine and anti-CCP was measured by spectrophotometrically and immunoassay. Mean +/- SE anti-CCP was higher significantly between AD [13.6 +/- 3] and healthy subjects [4.8 +/- 0.2] [P = 0.006]. In the patients, anti CCP serum level was in high range [32.1%] of abnormal levels, but there was no significant difference in serum homocysteine in AD patients compared with controls. There is no correlation between anti-CCP and homocysteine levels in AD patients [P = 0.75], but between age and anti-CCP level observed a significantly correlation [P = 0.04]. It needs more studies to clarify confirmation the role of anti-CCP antibody production in AD patients
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Peptídeos Cíclicos
/
Biomarcadores
/
Doença de Alzheimer
/
Homocisteína
/
Anticorpos
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Int. J. Prev. Med.
Ano de publicação:
2013
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