effect of Omega-3 supplements on antioxidant capacity in patients with type 2 diabetes

ABSTRACT

Diabetes is one of the most common chronic diseases in which antioxidant capacity changes. Omega-3 fatty acids have extensive biological effects including their advantage on lipoprotein metabolism, platelet function, cytokine production, clotting, fibrinolysis, and inflammatory factors. This study aimed to investigate the effect of omega-3 fatty acid supplements on antioxidant capacity in patients with type 2 diabetes. This clinical trial enrolled 71 women with type 2 diabetes in two case [treated with omega-3 capsules] and control [treated with placebo] groups. In the first stage, participants filled out a demographics questionnaire including age, height, weight, waist circumference, and hip circumference. Their blood sample was taken to evaluate glycosylated hemoglobin and antioxidant capacity. Then the case group received intervention for 8 weeks and weight, waist circumference, and hip circumference were measured and a blood sample was taken again. The data were analyzed using SPSS 18 software. The mean difference of antioxidant capacity before and after intervention was significant [P < 0.001]. Antioxidant capacity increased in the case group and reduced in the control group. With regard to the results of the present study, patients with type 2 diabetes increase their antioxidant capacity, enhance their antioxidant defense system, and probably prevent diabetes complications and related disease progress by taking omega-3 supplements